Endocrine Abstracts

Introduction: Adrenocortical carcinoma (ACC) is a rare neoplasm with a variable but overall poor prognosis. The presentation is heterogeneous usually with mass effect and less often with evidence of hormonal secretion. About half of cases the tumors are hormonally active most commonly with cortisol secretion followed by sexual hormones production, being rare the aldosterone secretion.Case report: A 41-year-old male presented with hypertensive crisis and ...

Introduction: Amyloidosis results from deposition of insoluble proteins in the extracellular space. It can be both primary or secondary to chronic inflammatory diseases. Although microscopic thyroid involvement is common, cases in which it becomes clinically evident (amyloid goiter) are rare.Case report: Woman, 45 years. In 2009, she was diagnosed with Crohn’s disease after Bartholin’s gland abscess excision and evaluation for weight loss, anem...

Background: Thyroid AUS/FLUS lesions continue to be a grey area regarding the surgery to be carried out. Our aim was to create a predictive malignancy score to help in surgical decision.Methods: Retrospective study of 2981 patients and 3557 thyroid Fine-needle aspirations (FNAs) between January 2012 to December 2014. Ultrasound and cytological findings considered suspicious by the ATA guidelines were analyzed. Malignant group was compared with a control ...

Introduction: The small-cell neuroendocrine prostate carcinoma (SCPC) is rare, highly aggressive and usually transforms from prostate adenocarcinoma (PAC) after androgen deprivation therapy (ADT).Case Report: A 66-year-old man had a three-year history of high-grade PAC with high burden disease (abdominal lymph node and bone metastasis) at presentation (09/2019). On the initial staging evaluation, the CT scan documented a 20 mm left adrenal nodule compati...

Introduction: Follicular thyroid cancer (FTC) accounts for 12% of differentiated thyroid cancers (DTC). It is frequently complicated by bone metastasis (BM), which impact quality of life (QOL) and decreases the 10-year survival rate to 13-21%.Case Report: A 53-year-old woman followed at the Pain Clinic for over 10 years for lower back pain, had been operated three years before due to lumbar disc herniation. Pain relapsed one year after surgery and was re...

Introduction: Nrf2 (Nfe2l2) is a transcription factor that regulates a series of cytoprotective and antioxidant enzymes. Upon exposure to oxidative or electrophilic stress, Nrf2 enters the nucleus and induces its target genes expression. Follicular thyroid cells have physiologically high levels of reactive oxygen species as oxidation of iodine is essential for iodination of thyroglobulin and thyroid hormones synthesis. We have shown previously that Nrf2 pathway is active in th...

IntroductionThe measurement of serum thyroglobulin (Tg), a glycoprotein produced exclusively by follicular thyroid cells, is an important tumour marker used in the follow-up of patients with differentiated thyroid carcinoma (DTC) and residual or recurrent disease. However, its role as a screening tool before thyroid surgery is not yet defined, as benign conditions can result in its increase.ObjectiveThe aim o...

Introduction: Calcium replacement after Thyroid surgery has been changing along times. The aim for this replacement is to avoid hypocalcaemia effects after thyroid surgery but not all the patients seem to need it. Parathyroid hormone (PTH) has a short half-life after its release into the bloodstream, making it a good marker of calcium metabolism in short time after surgery.Method: Prospective study of Endocrine Surgery Multidisciplinary group of one Cent...

IntroductionRadioiodine whole-body scintigraphy plays an important role in the follow-up of patients with differentiated thyroid carcinoma (DTC), as it is highly accurate in detecting thyroid residues and recurrent disease. Unusual 131-iodine uptake outside the thyroid bed and areas of physiological uptake is strongly suggestive of distant metastasis. However, uncommon uptake may occur and lead to diagnostic errors.Case report<...

Introduction: Fragility fractures are the main consequence of osteoporosis. It results in increased morbidity and mortality. The incidence of fractures has been increasing steadily in Portugal. Hip fragility fractures have been estimated to occur in up to 572/100,000/year in women and up to 232/100,000/year in men.Methods: A retrospective study of hospitalized patients for femoral neck fracture in our institution in 2018 was performed to evaluate their p...